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    <title>Spyre Therapeutics, Inc. (SYRE) - Company Filings</title>
    <link>https://www.developersdigest.tech/markets/syre/filings</link>
    <description>Latest company filings for Spyre Therapeutics, Inc. (SYRE) - annual reports, quarterly reports, major events, and insider trades, newest first.</description>
    <language>en</language>
    <lastBuildDate>Fri, 10 Jul 2026 07:48:54 GMT</lastBuildDate>
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      <title><![CDATA[SYRE: Insider sale notice (144)]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000195004726004262/xsl144X01/primary_doc.xml</link>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Insider sale notice (144) on 2026-05-08.]]></description>
      <pubDate>Fri, 08 May 2026 12:00:00 GMT</pubDate>
      <category>144</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Insider trade (4)]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000163628226000053/xslF345X06/wk-form4_1778290306.xml</link>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Insider trade (4) on 2026-05-08.]]></description>
      <pubDate>Fri, 08 May 2026 12:00:00 GMT</pubDate>
      <category>4</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Major company event (8-K)]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000163628226000051/syre-20260505.htm</link>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Major company event (8-K) on 2026-05-05.]]></description>
      <pubDate>Tue, 05 May 2026 12:00:00 GMT</pubDate>
      <category>8-K</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Quarterly report (10-Q)]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000163628226000050/syre-20260331.htm</link>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Quarterly report (10-Q) on 2026-05-05.]]></description>
      <pubDate>Tue, 05 May 2026 12:00:00 GMT</pubDate>
      <category>10-Q</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Insider trade (4)]]></title>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Insider trade (4) on 2026-05-01.]]></description>
      <pubDate>Fri, 01 May 2026 12:00:00 GMT</pubDate>
      <category>4</category>
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    <item>
      <title><![CDATA[SYRE: Insider sale notice (144)]]></title>
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      <pubDate>Fri, 01 May 2026 12:00:00 GMT</pubDate>
      <category>144</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Insider sale notice (144)]]></title>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Insider sale notice (144) on 2026-05-01.]]></description>
      <pubDate>Fri, 01 May 2026 12:00:00 GMT</pubDate>
      <category>144</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Insider trade (4)]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000185332726000005/xslF345X06/wk-form4_1777685708.xml</link>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Insider trade (4) on 2026-05-01.]]></description>
      <pubDate>Fri, 01 May 2026 12:00:00 GMT</pubDate>
      <category>4</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Insider trade (4)]]></title>
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      <pubDate>Fri, 01 May 2026 12:00:00 GMT</pubDate>
      <category>4</category>
    </item>
    <item>
      <title><![CDATA[SYRE: SCHEDULE 13G]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000119312526170304/xslSCHEDULE_13G_X02/primary_doc.xml</link>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a SCHEDULE 13G (SCHEDULE 13G) on 2026-04-22.]]></description>
      <pubDate>Wed, 22 Apr 2026 12:00:00 GMT</pubDate>
      <category>SCHEDULE 13G</category>
    </item>
    <item>
      <title><![CDATA[SYRE: SCHEDULE 13D/A]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000110465926045578/xslSCHEDULE_13D_X02/primary_doc.xml</link>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a SCHEDULE 13D/A (SCHEDULE 13D/A) on 2026-04-20.]]></description>
      <pubDate>Mon, 20 Apr 2026 12:00:00 GMT</pubDate>
      <category>SCHEDULE 13D/A</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Major company event (8-K)]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000162828026025508/syre-20260414.htm</link>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Major company event (8-K) on 2026-04-16.]]></description>
      <pubDate>Thu, 16 Apr 2026 12:00:00 GMT</pubDate>
      <category>8-K</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Prospectus supplement (424B5)]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000162828026025310/spyre-finalprosuppwithpfws.htm</link>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Prospectus supplement (424B5) on 2026-04-16.]]></description>
      <pubDate>Thu, 16 Apr 2026 12:00:00 GMT</pubDate>
      <category>424B5</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Prospectus supplement (424B5)]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000162828026024940/spyre-prelimprosuppwithpfw.htm</link>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Prospectus supplement (424B5) on 2026-04-13.]]></description>
      <pubDate>Mon, 13 Apr 2026 12:00:00 GMT</pubDate>
      <category>424B5</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Major company event (8-K)]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000162828026024906/syre-20260413.htm</link>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Major company event (8-K) on 2026-04-13.]]></description>
      <pubDate>Mon, 13 Apr 2026 12:00:00 GMT</pubDate>
      <category>8-K</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Major company event (8-K)]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000162828026024831/syre-20260413.htm</link>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Major company event (8-K) on 2026-04-13.]]></description>
      <pubDate>Mon, 13 Apr 2026 12:00:00 GMT</pubDate>
      <category>8-K</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Annual report to shareholders (ARS)]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000163628226000043/a2026arssubmission492026.pdf</link>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Annual report to shareholders (ARS) on 2026-04-10.]]></description>
      <pubDate>Fri, 10 Apr 2026 12:00:00 GMT</pubDate>
      <category>ARS</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Proxy materials (DEFA14A)]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000163628226000041/a2026spyredefa14amaterials.htm</link>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Proxy materials (DEFA14A) on 2026-04-10.]]></description>
      <pubDate>Fri, 10 Apr 2026 12:00:00 GMT</pubDate>
      <category>DEFA14A</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Proxy statement (DEF 14A)]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000163628226000039/syre-20260410.htm</link>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Proxy statement (DEF 14A) on 2026-04-10.]]></description>
      <pubDate>Fri, 10 Apr 2026 12:00:00 GMT</pubDate>
      <category>DEF 14A</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Insider trade (4)]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000185332726000003/xslF345X06/wk-form4_1775266173.xml</link>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Insider trade (4) on 2026-04-03.]]></description>
      <pubDate>Fri, 03 Apr 2026 12:00:00 GMT</pubDate>
      <category>4</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Insider trade (4)]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000175836326000007/xslF345X06/wk-form4_1775266241.xml</link>
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      <pubDate>Fri, 03 Apr 2026 12:00:00 GMT</pubDate>
      <category>4</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Insider trade (4)]]></title>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Insider trade (4) on 2026-04-03.]]></description>
      <pubDate>Fri, 03 Apr 2026 12:00:00 GMT</pubDate>
      <category>4</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Insider sale notice (144)]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000195004726003140/xsl144X01/primary_doc.xml</link>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Insider sale notice (144) on 2026-04-01.]]></description>
      <pubDate>Wed, 01 Apr 2026 12:00:00 GMT</pubDate>
      <category>144</category>
    </item>
    <item>
      <title><![CDATA[SYRE: SCHEDULE 13G/A]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000010290926002337/xslSCHEDULE_13G_X02/primary_doc.xml</link>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a SCHEDULE 13G/A (SCHEDULE 13G/A) on 2026-03-27.]]></description>
      <pubDate>Fri, 27 Mar 2026 12:00:00 GMT</pubDate>
      <category>SCHEDULE 13G/A</category>
    </item>
    <item>
      <title><![CDATA[SYRE: EFFECT]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/999999999526000722/xslEFFECTX01/primary_doc.xml</link>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a EFFECT (EFFECT) on 2026-03-04.]]></description>
      <pubDate>Wed, 04 Mar 2026 12:00:00 GMT</pubDate>
      <category>EFFECT</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Insider sale notice (144)]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000195004726002111/xsl144X01/primary_doc.xml</link>
      <guid isPermaLink="false">0001950047-26-002111</guid>
      <description><![CDATA[Spyre Therapeutics, Inc. filed a Insider sale notice (144) on 2026-03-03.]]></description>
      <pubDate>Tue, 03 Mar 2026 12:00:00 GMT</pubDate>
      <category>144</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Insider trade (4)]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000163628226000028/xslF345X05/wk-form4_1772591549.xml</link>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Insider trade (4) on 2026-03-03.]]></description>
      <pubDate>Tue, 03 Mar 2026 12:00:00 GMT</pubDate>
      <category>4</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Insider trade (4)]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000163628226000026/xslF345X05/wk-form4_1772591487.xml</link>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Insider trade (4) on 2026-03-03.]]></description>
      <pubDate>Tue, 03 Mar 2026 12:00:00 GMT</pubDate>
      <category>4</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Insider sale notice (144)]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000195004726001983/xsl144X01/primary_doc.xml</link>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Insider sale notice (144) on 2026-03-02.]]></description>
      <pubDate>Mon, 02 Mar 2026 12:00:00 GMT</pubDate>
      <category>144</category>
    </item>
    <item>
      <title><![CDATA[SYRE: EFFECT]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/999999999526000695/xslEFFECTX01/primary_doc.xml</link>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a EFFECT (EFFECT) on 2026-02-27.]]></description>
      <pubDate>Fri, 27 Feb 2026 12:00:00 GMT</pubDate>
      <category>EFFECT</category>
    </item>
    <item>
      <title><![CDATA[SYRE: POS AM]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000162828026012785/spyre-posamonsx3.htm</link>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a POS AM (POS AM) on 2026-02-27.]]></description>
      <pubDate>Fri, 27 Feb 2026 12:00:00 GMT</pubDate>
      <category>POS AM</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Company correspondence (CORRESP)]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000162828026011614/filename1.htm</link>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Company correspondence (CORRESP) on 2026-02-25.]]></description>
      <pubDate>Wed, 25 Feb 2026 12:00:00 GMT</pubDate>
      <category>CORRESP</category>
    </item>
    <item>
      <title><![CDATA[SYRE: SEC correspondence (UPLOAD)]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000000000026001931/filename1.pdf</link>
      <guid isPermaLink="false">0000000000-26-001931</guid>
      <description><![CDATA[Spyre Therapeutics, Inc. filed a SEC correspondence (UPLOAD) on 2026-02-25.]]></description>
      <pubDate>Wed, 25 Feb 2026 12:00:00 GMT</pubDate>
      <category>UPLOAD</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Employee stock plan (S-8)]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000163628226000024/spyre-february2026xsx8.htm</link>
      <guid isPermaLink="false">0001636282-26-000024</guid>
      <description><![CDATA[Spyre Therapeutics, Inc. filed a Employee stock plan (S-8) on 2026-02-19.]]></description>
      <pubDate>Thu, 19 Feb 2026 12:00:00 GMT</pubDate>
      <category>S-8</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Major company event (8-K)]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000163628226000022/syre-20260219.htm</link>
      <guid isPermaLink="false">0001636282-26-000022</guid>
      <description><![CDATA[Spyre Therapeutics, Inc. filed a Major company event (8-K) on 2026-02-19.]]></description>
      <pubDate>Thu, 19 Feb 2026 12:00:00 GMT</pubDate>
      <category>8-K</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Annual report (10-K)]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000163628226000020/syre-20251231.htm</link>
      <guid isPermaLink="false">0001636282-26-000020</guid>
      <description><![CDATA[Spyre Therapeutics, Inc. filed a Annual report (10-K) on 2026-02-19.]]></description>
      <pubDate>Thu, 19 Feb 2026 12:00:00 GMT</pubDate>
      <category>10-K</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Securities registration (S-3)]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000162828026009814/spyre-sx3.htm</link>
      <guid isPermaLink="false">0001628280-26-009814</guid>
      <description><![CDATA[Spyre Therapeutics, Inc. filed a Securities registration (S-3) on 2026-02-19.]]></description>
      <pubDate>Thu, 19 Feb 2026 12:00:00 GMT</pubDate>
      <category>S-3</category>
    </item>
    <item>
      <title><![CDATA[SYRE: SCHEDULE 13G/A]]></title>
      <link>https://www.sec.gov/Archives/edgar/data/1636282/000121465926002024/xslSCHEDULE_13G_X01/primary_doc.xml</link>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a SCHEDULE 13G/A (SCHEDULE 13G/A) on 2026-02-17.]]></description>
      <pubDate>Tue, 17 Feb 2026 12:00:00 GMT</pubDate>
      <category>SCHEDULE 13G/A</category>
    </item>
    <item>
      <title><![CDATA[SYRE: Insider trade (4)]]></title>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Insider trade (4) on 2026-02-04.]]></description>
      <pubDate>Wed, 04 Feb 2026 12:00:00 GMT</pubDate>
      <category>4</category>
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    <item>
      <title><![CDATA[SYRE: Insider trade (4)]]></title>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Insider trade (4) on 2026-01-23.]]></description>
      <pubDate>Fri, 23 Jan 2026 12:00:00 GMT</pubDate>
      <category>4</category>
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      <title><![CDATA[SYRE: Insider trade (4)]]></title>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Insider trade (4) on 2026-01-13.]]></description>
      <pubDate>Tue, 13 Jan 2026 12:00:00 GMT</pubDate>
      <category>4</category>
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      <title><![CDATA[SYRE: Insider trade (4)]]></title>
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      <pubDate>Tue, 13 Jan 2026 12:00:00 GMT</pubDate>
      <category>4</category>
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      <title><![CDATA[SYRE: Insider trade (4)]]></title>
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      <pubDate>Tue, 13 Jan 2026 12:00:00 GMT</pubDate>
      <category>4</category>
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      <title><![CDATA[SYRE: Insider trade (4)]]></title>
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      <pubDate>Tue, 13 Jan 2026 12:00:00 GMT</pubDate>
      <category>4</category>
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      <title><![CDATA[SYRE: Major company event (8-K)]]></title>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Insider trade (4) on 2025-12-03.]]></description>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Major company event (8-K) on 2025-11-04.]]></description>
      <pubDate>Tue, 04 Nov 2025 12:00:00 GMT</pubDate>
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      <title><![CDATA[SYRE: Quarterly report (10-Q)]]></title>
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      <description><![CDATA[Spyre Therapeutics, Inc. filed a Quarterly report (10-Q) on 2025-11-04.]]></description>
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