| 1 |  Eli Lilly and CompanyLLY | Pharmaceutical Preparations | $1.082 T |
| 2 |  Johnson & JohnsonJNJ | Pharmaceutical Preparations | $663.28 B |
| 3 |  AbbVie Inc.ABBV | Pharmaceutical Preparations | $453.11 B |
| 4 |  Merck & Co., Inc.MRK | Pharmaceutical Preparations | $371.29 B |
| 5 |  Novartis AGNVS | Pharmaceutical Preparations | $305.29 B |
| 6 |  AstraZeneca PLCAZN | Pharmaceutical Preparations | $286.27 B |
| 7 |  GSK plcGSK | Pharmaceutical Preparations | $215.30 B |
| 8 |  Novo Nordisk A/SNVO | Pharmaceutical Preparations | $202.94 B |
| 9 |  Abbott LaboratoriesABT | Pharmaceutical Preparations | $188.69 B |
| 10 |  Pfizer Inc.PFE | Pharmaceutical Preparations | $162.15 B |
| 11 |  Vertex Pharmaceuticals IncorporatedVRTX | Pharmaceutical Preparations | $138.61 B |
| 12 |  Bristol-Myers Squibb CompanyBMY | Pharmaceutical Preparations | $136.45 B |
| 13 |  Regeneron Pharmaceuticals, Inc.REGN | Pharmaceutical Preparations | $56.80 B |
| 14 |  SanofiSNY | Pharmaceutical Preparations | $53.95 B |
| 15 |  Teva Pharmaceutical Industries LimitedTEVA | Pharmaceutical Preparations | $42.34 B |
| 16 |  Alnylam Pharmaceuticals, Inc.ALNY | Pharmaceutical Preparations | $35.29 B |
| 17 | OBeOne Medicines AGONC | Pharmaceutical Preparations | $32.14 B |
| 18 |  Zoetis Inc.ZTS | Pharmaceutical Preparations | $31.78 B |
| 19 | IInsmed IncorporatedINSM | Pharmaceutical Preparations | $27.37 B |
| 20 |  Roivant Sciences Ltd.ROIV | Pharmaceutical Preparations | $25.12 B |
| 21 |  Takeda Pharmaceutical Company LimitedTAK | Pharmaceutical Preparations | $24.43 B |
| 22 | RRoyalty Pharma plcRPRX | Pharmaceutical Preparations | $21.16 B |
| 23 | UUnited Therapeutics CorporationUTHR | Pharmaceutical Preparations | $20.70 B |
| 24 |  Viatris Inc.VTRS | Pharmaceutical Preparations | $19.66 B |
| 25 | AAscendis Pharma A/SASND | Pharmaceutical Preparations | $16.77 B |
| 26 | GGenmab A/SGMAB | Pharmaceutical Preparations | $16.27 B |
| 27 |  Jazz Pharmaceuticals plcJAZZ | Pharmaceutical Preparations | $15.49 B |
| 28 |  BridgeBio Pharma, Inc.BBIO | Pharmaceutical Preparations | $14.66 B |
| 29 |  Summit Therapeutics Inc.SMMT | Pharmaceutical Preparations | $13.66 B |
| 30 |  BioMarin Pharmaceutical Inc.BMRN | Pharmaceutical Preparations | $12.86 B |
| 31 | MMadrigal Pharmaceuticals, Inc.MDGL | Pharmaceutical Preparations | $12.47 B |
| 32 |  Elanco Animal Health IncorporatedELAN | Pharmaceutical Preparations | $12.24 B |
| 33 |  Arrowhead Pharmaceuticals, Inc.ARWR | Pharmaceutical Preparations | $12.16 B |
| 34 |  Corcept Therapeutics IncorporatedCORT | Pharmaceutical Preparations | $11.98 B |
| 35 |  Axsome Therapeutics, Inc.AXSM | Pharmaceutical Preparations | $10.64 B |
| 36 |  Dr. Reddy's Laboratories LimitedRDY | Pharmaceutical Preparations | $9.99 B |
| 37 | PPraxis Precision Medicines, Inc.PRAX | Pharmaceutical Preparations | $9.81 B |
| 38 | IIonis Pharmaceuticals, Inc.IONS | Pharmaceutical Preparations | $9.60 B |
| 39 | PProtagonist Therapeutics, Inc.PTGX | Pharmaceutical Preparations | $9.37 B |
| 40 |  Cytokinetics, IncorporatedCYTK | Pharmaceutical Preparations | $9.05 B |
| 41 | AABIVAX Société AnonymeABVX | Pharmaceutical Preparations | $9.02 B |
| 42 | CCrinetics Pharmaceuticals, Inc.CRNX | Pharmaceutical Preparations | $8.96 B |
| 43 | NNuvalent, Inc.NUVL | Pharmaceutical Preparations | $8.64 B |
| 44 |  TG Therapeutics, Inc.TGTX | Pharmaceutical Preparations | $8.57 B |
| 45 |  Legend Biotech CorporationLEGN | Pharmaceutical Preparations | $7.96 B |
| 46 | SSpyre Therapeutics, Inc.SYRE | Pharmaceutical Preparations | $7.73 B |
| 47 |  Alkermes plcALKS | Pharmaceutical Preparations | $7.68 B |
| 48 | BBelite Bio, IncBLTE | Pharmaceutical Preparations | $7.62 B |
| 49 |  Rhythm Pharmaceuticals, Inc.RYTM | Pharmaceutical Preparations | $7.04 B |
| 50 |  Grifols, S.A.GRFS | Pharmaceutical Preparations | $6.77 B |
| 51 | CCentessa Pharmaceuticals plcCNTA | Pharmaceutical Preparations | $6.27 B |
| 52 |  Mirum Pharmaceuticals, Inc.MIRM | Pharmaceutical Preparations | $6.15 B |
| 53 |  Terns PharmaceuticalsTERN | Pharmaceutical Preparations | $6.12 B |
| 54 |  Liquidia CorporationLQDA | Pharmaceutical Preparations | $6.11 B |
| 55 | TTravere Therapeutics, Inc.TVTX | Pharmaceutical Preparations | $6.07 B |
| 56 |  PTC Therapeutics, Inc.PTCT | Pharmaceutical Preparations | $6.03 B |
| 57 | CCogent Biosciences, Inc.COGT | Pharmaceutical Preparations | $5.94 B |
| 58 | DDianthus Therapeutics, Inc.DNTH | Pharmaceutical Preparations | $5.91 B |
| 59 | XXenon Pharmaceuticals Inc.XENE | Pharmaceutical Preparations | $5.78 B |
| 60 | LLigand Pharmaceuticals IncorporatedLGND | Pharmaceutical Preparations | $5.72 B |
| 61 | OOruka Therapeutics, Inc.ORKA | Pharmaceutical Preparations | $5.58 B |
| 62 |  Amneal Pharmaceuticals, Inc.AMRX | Pharmaceutical Preparations | $5.56 B |
| 63 | AApellis PharmaceuticalsAPLS | Pharmaceutical Preparations | $5.25 B |
| 64 | EErasca, Inc.ERAS | Pharmaceutical Preparations | $5.03 B |
| 65 |  ACADIA Pharmaceuticals Inc.ACAD | Pharmaceutical Preparations | $4.80 B |
| 66 | EEdgewise Therapeutics, Inc.EWTX | Pharmaceutical Preparations | $4.63 B |
| 67 |  Amicus TherapeuticsFOLD | Pharmaceutical Preparations | $4.55 B |
| 68 |  Indivior PLCINDV | Pharmaceutical Preparations | $4.26 B |
| 69 | MVeradermics, IncorporatedMANE | Pharmaceutical Preparations | $4.12 B |
| 70 |  Viking Therapeutics, Inc.VKTX | Pharmaceutical Preparations | $4.05 B |
| 71 |  Telix Pharmaceuticals LimitedTLX | Pharmaceutical Preparations | $4.04 B |
| 72 |  Dyne Therapeutics, Inc.DYN | Pharmaceutical Preparations | $4.01 B |
| 73 |  Catalyst Pharmaceuticals, Inc.CPRX | Pharmaceutical Preparations | $3.85 B |
| 74 |  Amylyx Pharmaceuticals, Inc.AMLX | Pharmaceutical Preparations | $3.79 B |
| 75 | KKiniksa Pharmaceuticals International, plcKNSA | Pharmaceutical Preparations | $3.75 B |
| 76 |  Arcus Biosciences, Inc.RCUS | Pharmaceutical Preparations | $3.73 B |
| 77 |  Organon & Co.OGN | Pharmaceutical Preparations | $3.62 B |
| 78 | EEnliven Therapeutics, Inc.ELVN | Pharmaceutical Preparations | $3.61 B |
| 79 | IIDEAYA Biosciences, Inc.IDYA | Pharmaceutical Preparations | $3.50 B |
| 80 |  AbCellera Biologics Inc.ABCL | Pharmaceutical Preparations | $3.49 B |
| 81 | TTango Therapeutics, Inc.TNGX | Pharmaceutical Preparations | $3.26 B |
| 82 | IImmunome, Inc.IMNM | Pharmaceutical Preparations | $3.03 B |
| 83 | IDisc Medicine, Inc.IRON | Pharmaceutical Preparations | $3.03 B |
| 84 | AArcutis Biotherapeutics, Inc.ARQT | Pharmaceutical Preparations | $2.99 B |
| 85 | NNewAmsterdam Pharma Company N.V.NAMS | Pharmaceutical Preparations | $2.97 B |
| 86 | MMBX Biosciences, Inc.MBX | Pharmaceutical Preparations | $2.94 B |
| 87 | GStructure Therapeutics Inc.GPCR | Pharmaceutical Preparations | $2.81 B |
| 88 | QuniQure N.V.QURE | Pharmaceutical Preparations | $2.81 B |
| 89 | SSoleno TherapeuticsSLNO | Pharmaceutical Preparations | $2.76 B |
| 90 | AAlumis Inc.ALMS | Pharmaceutical Preparations | $2.74 B |
| 91 | NNurix Therapeutics, Inc.NRIX | Pharmaceutical Preparations | $2.70 B |
| 92 | AAtaiBeckley Inc.ATAI | Pharmaceutical Preparations | $2.68 B |
| 93 | SSELLAS Life Sciences Group, Inc.SLS | Pharmaceutical Preparations | $2.58 B |
| 94 | VVera Therapeutics, Inc.VERA | Pharmaceutical Preparations | $2.58 B |
| 95 |  Precigen, Inc.PGEN | Pharmaceutical Preparations | $2.53 B |
| 96 | SSupernus Pharmaceuticals, Inc.SUPN | Pharmaceutical Preparations | $2.53 B |
| 97 |  Nektar TherapeuticsNKTR | Pharmaceutical Preparations | $2.51 B |
| 98 |  Prestige Consumer Healthcare Inc.PBH | Pharmaceutical Preparations | $2.48 B |
| 99 | TTrevi Therapeutics, Inc.TRVI | Pharmaceutical Preparations | $2.45 B |
| 100 |  Bausch Health Companies Inc.BHC | Pharmaceutical Preparations | $2.45 B |